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gyurza venom (venenum macroviperae lebetina), containing phospholipase, phosphodiesterase, hyaluronidase, as well as other active substances, is a key active ingredient in the vipratox liniment. The pharmacological action of Vipratox liniment is caused by toxins that make up the gyurza venom. postsynaptic neurotoxins provide a specific blockade of n-cholinergic receptors of the subsynaptic membrane of skeletal muscle and certain parts of the central nervous system. presynaptic nerve endings are affected by presynaptic neurotoxins, which contribute to increased secretion of mediators. actively acting on cell membranes, membrane-active neurotoxins (cardiotoxins, cytoxins, which are polypeptides in chemical structure), including their depolarization.
Along with a specific effect that directly depends on the composition of the poison, the therapeutic effect of the drug is caused by reflex reactions, the occurrence of which is associated with irritation of the skin receptors, the action of biogenic substances generated by the local action of the drug on the tissues, the effect on the bodys immune system reactions and stimulation of the hypothalamic-pituitary -adrenal axis. When applied locally, gyurza venom has an irritating and analgesic effect.
When applied externally, salicylic acid has an antiseptic, distracting, irritating and keratolytic effect, contributing to the optimal penetration of the active ingredients of the ointment.
Due to its excellent lipophilicity, fir oil easily penetrates the epidermis and irritates the ends of the sensory nerves of both the superficial vessels and deeper tissues.
Due to the inclusion of camphor, the drug has a locally irritating, analgesic and anti-inflammatory effect and, by exciting sensitive nerve endings of the skin, improves tissue trophism.
Pharmacokinetics Not studied.
Symptomatic pain therapy for rheumatism, neuralgia, sciatica, lumbago, radiculitis, myalgia, arthralgia.
To avoid side effects, you should first apply a small amount of liniment on the skin in order to determine individual sensitivity to the drug.
Depending on the surface area of the painful area, the liniment should be applied in a small amount of 5–10 g and rubbed thoroughly into the skin 1–2 r / day until the pain syndrome ceases.
The duration of the course of therapy is determined by the doctor depending on the severity of the disease and the effectiveness of the therapy.
Children. There is no experience with children, therefore, the use of the drug in this category of patients is not recommended.
Hypersensitivity to the drug. BA, pertussis, tendency to bronchospasm and seizures, acute pulmonary tuberculosis, impaired cerebral and coronary circulation, tendency to spasm of blood vessels, severe impairment of kidney and liver functions, pustular skin diseases, damage to the integrity of the skin at the site of application of the drug, fever, general fatigue.
Local allergic reactions are possible (including itching, burning, rash, dryness, peeling, irritation, contact dermatitis, urticaria), fever.
Do not apply to the skin with an allergic reaction.
Avoid contact with eyes, open wounds and mucous membranes. In case of accidental contact with eyes or mucous membranes, rinse thoroughly with plenty of running water.
Use with caution in the elderly.
Use during pregnancy and lactation. Contraindicated during pregnancy and lactation.
The ability to influence the reaction rate when driving vehicles or working with other mechanisms. The drug does not affect the reaction rate when driving vehicles or working with other mechanisms.
Not studied. a sufficient number of controlled studies of drug interaction have not been conducted, it is possible that excessive use of salicylates for topical use can increase the effect of coumarin anticoagulants and antiplatelet drugs. patients taking coumarin anticoagulants and antiplatelet drugs, including acetylsalicylic acid, should be careful.
In case of accidental contact with the mucous membranes, the ointment causes severe irritation. allergic reactions (itching, dermatitis, peeling of the skin) are possible. you should stop using liniment and wash off its remnants from the skin. if necessary, symptomatic therapy is indicated.
Incorrect use. Accidentally swallowing the ointment can cause symptoms of the digestive tract, such as vomiting and diarrhea. Therapy is symptomatic.
If a large amount of the ointment is accidentally swallowed, symptoms of acute poisoning, such as nausea, vomiting, abdominal pain, headache, dizziness, sensation of heat / redness, cramps, respiratory depression, and coma, can occur.
Therapy of patients with severe gastrointestinal or neurological symptoms of poisoning is symptomatic. Do not induce vomiting.
At a temperature of 8–20 ° c.