Venohepanol

Pharmacological properties

Venohepanol is an antithrombotic, decongestant with anti-inflammatory effect for external use. heparin, which is part of the drug, has a local antithrombotic, decongestant, and anti-inflammatory effect. venorutinol has a venotonic and angioprotective effect, normalizes the permeability of the walls of capillaries, increases their tone due to p-vitamin activity and improved microcirculation and trophic tissue. dexpanthenol stimulates granulation and epithelization of tissues, forming an active metabolite - pantothenic acid, which takes part in the synthesis of coenzyme a.

Indications

Prevention and treatment of varicose veins, including after surgical interventions; thrombosis, thrombophlebitis; closed injuries (including sports) with hematomas, sprains; infiltrates; cicatricial induction and external inflammatory processes without violating the integrity of the skin; tenosynovitis.

Application

The drug is used externally. for adults, the gel is applied to the intact skin of the affected area 1-3 times a day. in the treatment of vein diseases, the drug is used in the form of dressings with a gel. with varicose ulcers, the gel is applied in the form of a ring with a diameter of 4 cm around the ulcer. Avoid applying the gel directly to the ulcer surface!

The duration of treatment is determined by the doctor individually and depends on the clinical indications and the course of the disease. In the treatment of injuries (including sports) with hematomas, the duration of treatment is 5-7 days.

Contraindications

Individual hypersensitivity to any of the components of the drug, hemophilia, hemorrhagic diathesis, idiopathic thrombocytopenic purpura, severe thrombocytopenia, ulcerative necrotic processes in the thrombophlebitis zone, tendency to bleedings, bleeding, traumatic violations of the integrity of the skin, open and / or.

Side effects

In some cases, local hypersensitivity reactions are possible - hyperemia, skin irritation, itching, rash, including urticaria, angioedema, dermatitis, eczema, allergic reactions, contact dermatitis, irritation, burning sensation, swelling of the skin, hemorrhage, sometimes - the appearance of small pustules bubbles or bubbles. when applied to large areas of the skin, systemic adverse reactions are possible. usually these symptoms disappear on their own after discontinuation of the drug.

In the event of any adverse reactions, you should always consult your doctor regarding the further use of the drug.

special instructions

The gel is applied only to intact skin.

Do not apply to the wound surface of the skin and make sure that the drug does not get into the eyes and mucous membranes. Can be applied under an occlusive dressing. After applying the gel, it is necessary to avoid exposure to sunlight on the treated areas of the skin.

Patients with chronic venous insufficiency are recommended to use the drug both at the initial and late stages of the disease (the feeling of heaviness in the legs, swelling of the lower extremities decreases, trophism improves).

In severe renal impairment, prolonged use of the drug is not recommended.

Venohepanol is used with caution in case of bleeding (in this case, coagulation control is necessary during treatment).

If the gel gets into your eyes, rinse them with water. In case of accidental ingestion of a large amount of gel, induce vomiting and consult a doctor.

If the signs of the disease do not begin to disappear or, conversely, the health condition worsens, or undesirable effects occur, it is necessary to suspend the use of the drug and seek the advice of a doctor regarding further use.

Use during pregnancy and lactation. The drug is not used during pregnancy and lactation.

Children. Do not use.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. The drug Venohepanol does not affect the reaction rate when driving vehicles or working with other mechanisms.

Interactions

The simultaneous use of the drug and dextran, phenylbutazone, ketorolac can increase the risk of bleeding.

Parenteral administration of nitroglycerin with the use of Venohepanol, as well as the simultaneous use of a gel with thyroxine, tetracycline, antihistamines, ergot alkaloids, nicotine, can weaken the effect of the drug.

Oral anticoagulants (e.g. warfarin, dicumarol, clopidogrel) simultaneously with the use of Venohepanol gel can cause an increase in prothrombin time.

NSAIDs (for example, diclofenac, ibuprofen, indomethacin), venotonic drugs with simultaneous use enhance the effect of Venogepanol gel.

Enhances the effect of ascorbic acid on the structure and permeability of the vascular wall.

ACE inhibitors, aliskiren: possible hyperglycemia.

Dipyridamole, iloprost increase the anticoagulant effect of the active substance Venohepanol - heparin.

The simultaneous use of venohepanol with drugs containing sulindac can lead to the development of peripheral neuropathy.

Dexpanthenol, which is part of Venohepanol, can enhance the effect of depolarizing muscle relaxants (e.g. suxamethonium chloride, decamethonium bromide) and weaken the effect of non-depolarizing muscle relaxants (e.g. tubocurarine chloride) due to its ability to stimulate the synthesis of acetylcholine.

If the patient takes any other medicines, be sure to inform your doctor.

Overdose

Symptoms subject to the indicated dosage regimen, an overdose is unlikely. when applied to large areas of the skin (due to possible systemic absorption) hemorrhagic complications in the form of bleeding of varying severity are possible.

Treatment. With slight bleeding, the dose should be reduced or the use of the drug temporarily discontinued. In case of severe bleeding, 1% protamine sulfate solution is slowly administered iv. If the concentration of heparin in the blood is unknown, then a single dose of protamine sulfate should not exceed 1 ml. If indicated, peritoneal dialysis is performed. Therapy is symptomatic.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.