Valerian Rhizomes with Roots

Pharmacological properties

the drug has a sedative effect, restores the macrostructure of sleep, stabilizes autonomic functions.

Means of plant origin. The action is due to the ester of borneol and isovalerianic acid, valepotriate and alkaloids (valerin, hotenin). The drug improves the effectiveness and quality of sleep. Sedation is slow, but stable enough. Valerianic acid and valepotriates have a weak antispasmodic effect. In addition, the complex of biologically active substances of Valerian officinalis exerts a choleretic effect, enhances the secretory activity of the mucous membrane of the digestive tract, slows down the heart rhythm and dilates the coronary vessels. Regulation of cardiac activity is carried out through neurohumoral mechanisms and a direct effect on automatism and the conduction system of the heart. The therapeutic effect is manifested with a systematic and prolonged course of treatment. The drug causes a decrease in spontaneous and increased excitability of the central nervous system, has a moderate anticonvulsant effect. The drug does not have a local irritant effect.

Pharmacokinetics Not studied.

Indications

Increased nervous irritability, insomnia; as part of combination therapy - for mild functional disorders of the cardiovascular system.

Application

Assign by mouth to adults 1 capsule 3 times a day.

The duration of treatment is determined by the doctor individually.

Contraindications

Hypersensitivity to valerian or other components of the drug; arterial hypotension; depression or other conditions accompanied by inhibition of central nervous system activity, drowsiness; cholelithiasis.

Side effects

Nervous system: headache, dizziness, lethargy, drowsiness, depression of emotional reactions, depression, general weakness, decreased mental and physical performance, concentration of attention; in some cases - mental agitation, anxiety, insomnia.

Cardiovascular system: arterial hypotension, a feeling of squeezing behind the sternum, a feeling of palpitations, pain in the heart, heart rhythm disturbance (including bradycardia, tachycardia).

Digestive tract: nausea, diarrhea, cramping and abdominal pain, with prolonged use, inhibition of the digestive process, constipation are possible.

Hepatobiliary system: possible manifestations of hepatotoxicity.

Immune system: allergic reactions, including skin rashes, itching, urticaria, hyperemia, edema, shortness of breath, asthma.

Adverse reactions occur extremely rarely, are reversible, usually develop with the use of the drug for a long time and a significant excess of the recommended doses.

In the event of any adverse events, the patient should always consult a doctor.

special instructions

Do not exceed recommended doses of the drug.

When using the drug should refrain from drinking alcoholic beverages.

Caution should be exercised in patients with a history of severe hepatic impairment or a history of severe liver disease.

Valerian can cause a moderate depressive effect, therefore, the combined use of the drug with synthetic sedatives is not recommended due to the potentiation of the effect.

With severe atherosclerosis of the cerebral vessels, the drug can be used only under the supervision of a doctor.

The drug contains a dye ponso 4R (E124), which can cause allergic reactions, including AD. The risk of allergies is higher in patients with hypersensitivity to acetylsalicylic acid.

Possible specific sensitivity to the smell of valerian.

Use during pregnancy and lactation.It is not recommended to use the drug during pregnancy and lactation due to insufficient data on the safety of its use during these periods.

Children. The drug is not used in children.

The ability to influence the reaction rate when driving vehicles or other mechanisms. When using the drug should refrain from driving vehicles or working with other mechanisms.

Interactions

Valerika enhances the effect of sleeping pills, tranquilizers, sedatives, anxiolytic, analgesic, antispasmodic drugs, central antihypertensive drugs, antipsychotics, ethyl alcohol, nootropic drugs, drugs for anesthesia, curare-like muscle relaxants.

Combined use with synthetic sedatives is not recommended.

Concomitant use of alcohol should also be avoided.

Overdose

Symptoms: possible fatigue, general weakness, headache, dizziness, drowsiness, cramping and abdominal pain, nausea, chest tightness, tachycardia, trembling hands and dilated pupils, decreased hearing and visual acuity.

Treatment: stop using the drug, rinse the stomach, take activated charcoal. If necessary, carry out symptomatic therapy.

There have been reports of the development of withdrawal syndrome (delirium) after taking very high doses of valerian root for several years (about 30 g / day).

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.