Tranexamic acid

Acemic film-coated tablets are indicated for bleeding or risk of bleeding with increased local fibrinolysis:

• menorrhagia;
• bleeding after prostatectomy or surgery on the bladder;
• conization of the cervix;
• epistaxis posttraumatic hyphema.

Structure

Active ingredient: tranexamic acid;

1 coated tablet contains tranexamic acid - 500 mg;

Excipients: microcrystalline cellulose, corn starch, croscarmellose sodium, stearic acid, colloidal silicon dioxide, magnesium stearate;

Tablet shell: Opadry White (hydroxypropyl methylcellulose, titanium dioxide (E 171), polyethylene glycol, polysorbate 80).

Contraindications

Hypersensitivity to tranexamic acid and to the components that make up the drug, severe renal failure, macroscopic hematuria, a high risk of thrombosis, thrombophlebitis, myocardial infarction, subarachnoid hemorrhage, active thromboembolic disease, venous or arterial thrombosis, or history of acute venous thrombosis fibrinolytic conditions after coagulopathy due to exhaustion, with the exception of excessive activation of the fibrinolytic system in acute severe bleeding, convulsions in the history of a violation of the perception of colors.

Mode of application

For adults, the drug is prescribed orally. Applied regardless of food intake. The tablets are swallowed whole, washed down with water. Tablets should not be chewed and crushed.

Application features

Pregnant women

It is possible to prescribe the drug only when the expected benefit for the pregnant woman exceeds the potential risk to the fetus.

Children

There is no clinical experience with tranexamic acid in children under 15 years of age with menorrhagia, therefore, this drug should not be used in this category of patients.

Drivers

During the use of the drug should refrain from driving and working with mechanisms.

Overdose

Symptoms: nausea, vomiting, abdominal pain, orthostatic hypotension, arterial hypotension, dizziness, headache, convulsions or increased manifestations of other adverse reactions, including the risk of thrombosis.

Treatment: induce vomiting, rinse the stomach, take activated charcoal. High fluid intake is required to promote renal excretion. Symptomatic treatment is used and, if necessary, anticoagulant therapy.

Side effects

• From the digestive tract: nausea, vomiting, heartburn, diarrhea, abdominal pain, decreased appetite.
• On the part of the skin and subcutaneous tissue: rash, itching, urticaria, allergic skin reactions.
• From the nervous system: drowsiness, dizziness, convulsions.
• From the side of the organ of vision: impaired color perception, impaired vision, congestive retinopathy, occlusion of veins / arteries of the retina.
• From the immune system: hypersensitivity reactions, including anaphylaxis.
• Vascular disorders: thrombosis of any localization, thromboembolism, arterial hypotension.
• From the side of the kidneys: acute necrosis of the cortical layer of the kidneys.

Interaction

Tranexamic acid is incompatible with urokinase, norepinephrine bitartrate, deoxypinephrine hydrochloride, metarmine bitartrate, dipyridamole, diazepam.

Storage conditions

Store in the original packaging at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life is 2 years.