tocopherol acetate

Pharmacological properties

Tocopherol in the body increases the protective properties of cell membranes. tocopherol enters the bloodstream, mainly with lymph, the maximum concentration in the blood plasma is reached 4-8 hours after ingestion and after 1 day again returns to its original level. tocopherol is excreted in the bile. since the concentration of α-tocopherol in bile is stable, in contrast to the concentration in blood plasma, sharp fluctuations in the concentration of vitamin e in blood plasma are not displayed at the level of vitamin e in bile.

Indications

The drug is prescribed in the treatment of infertility; as an adjunct therapy for menstrual irregularities, for symptoms of vitamin e deficiency, for the treatment of gastrointestinal tract diseases, musculoskeletal system diseases, neurological diseases, endocrine gland dysfunctions, malnutrition, liver diseases, nutritional anemia, skin diseases, sensorineural hearing loss, as part of antioxidant therapy.

Application

Doses are selected individually, depending on the characteristics of the disease. the average duration of use is from 1-3 weeks to 2-3 months. in the absence of other indications, in adults apply:

- with infertility, menstrual irregularities (in combination with hormonal therapy) - 400 mg every other day, repeating 5 times, starting from the 17th day of the cycle;

- for rheumatoid diseases - 400 mg daily for several weeks;

- with primary muscular dystrophy - up to 2000 mg / day, with other neurological indications, 400 mg / day is enough for 30-60 days;

- in case of alimentary anemia - 400 mg / day for 10 days;

- in case of chronic hepatitis with exacerbations, treatment with a daily dose of 400 mg is prescribed for several months;

- for diseases of the endocrine system - 400 mg daily;

- as part of antioxidant therapy, apply 400 mg 1-2 times a day.

Children over the age of 12 are prescribed 400 mg / day.

The capsule is swallowed whole, washed down with a sufficient amount of neutral liquid.

Contraindications

Hypersensitivity to any of the components of the drug.

Side effects

Typically, the drug is well tolerated, but with prolonged treatment or after taking high doses in exceptional cases, digestion, fatigue, weakness, and headache are possible. the use of vitamin E in high doses can increase blood clotting disorder caused by a lack of vitamin K.

special instructions

Caution must be exercised when using vitamin E in patients with severe cardiosclerosis and in acute myocardial infarction.

Children. Do not prescribe to children under the age of 12 years in a dosage of 400 mg.

During pregnancy and breastfeeding. The drug can be used during pregnancy and lactation only under the strict supervision of a physician.

The ability to influence the reaction rate when driving vehicles and working with other mechanisms. Does not affect.

Interactions

Vitamin E facilitates the absorption and assimilation of vitamin a and prevents the development of vitamin deficiency a. at a dose of 10 mg / kg / day, vitamin E slows down the therapeutic effect of iron when used in children with iron deficiency anemia. in children with low birth weight who use iron supplements, vitamin E deficiency can cause hemolytic anemia.

Vitamin E or its metabolites are antagonists of vitamin K. In patients who have used oral anticoagulants, prolonged administration of vitamin E can cause hemorrhages.

There is evidence that vitamin E can increase the effectiveness of anticonvulsants in patients with epilepsy, in whose blood an increased content of lipid peroxidation products was detected.

Overdose

With oral administration of the drug in recommended doses, adverse reactions do not develop.when taking the drug in high doses (400 mg / day for a long time), dyspepsia, fatigue, general weakness, headache are possible. creatinuria, an increase in the activity of creatine kinase, an increase in the concentration of cholesterol, tg, a decrease in the concentration of thyroxine and triiodothyronine in the blood plasma, an increase in the level of estrogen and androgen in the urine are also noted.

There is no specific antidote, the treatment is symptomatic.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C.