

Braxon injection solution is indicated for severe infectious diseases caused by microorganisms that are sensitive to the drug:
Active substance: tobramycin;
1 ml of tobramycin (in the form of sulfate) - 40 mg;
Excipients: sodium edetate, sodium sulfite anhydrous, water for injection.
Hypersensitivity to tobramycin or other aminoglycoside antibiotics.
Neuritis of the auditory nerve, severe chronic renal failure.
The drug is used intramuscularly (i / m) or intravenously (i / v) drip. For IM use, the appropriate dose is administered directly from the ampoule.
For iv administration, the solution is diluted in 100-200 ml of 0.9% sodium chloride solution or 5% glucose solution, administered for 20-60 minutes.
It should be prescribed to pregnant women only in cases where the potential benefit significantly exceeds the potential risk.
Apply from the first days of life.
The drug is used in a hospital setting.
Symptoms: toxic reactions (hearing loss, ataxia, dizziness, urination disorder, thirst, loss of appetite, nausea, vomiting, tinnitus or a feeling of stuffy ears, nephronecrosis - increased urea concentration, hypercreatininemia, proteinuria, oliguria), respiratory muscles paralysis.
Treatment of patients with normal renal function is carried out by fluid infusion and forced diuresis; patients with impaired renal function - hemodialysis or peritoneal dialysis. In case of neuromuscular blockade - anticholinesterase drugs, calcium salts during respiratory arrest - mechanical ventilation, other symptomatic and supportive therapy.
Tobramycin enhances the action of non-depolarizing muscle relaxants.
Reduces the effect of anti-myasthenic drugs.
Aminoglycosides, cephalosporins, vancomycin, polymyxin, diuretics increase the risk of oto- and nephrotoxicity.
Beta-lactam antibiotics weaken the effect.
Intravenous administration of indomethacin reduces the renal clearance of tobramycin,increasing the concentration in the blood and increases the half-life (T 1/2) (may require correction of the dosage regimen).
Methoxyflurane increases the risk of adverse reactions.
Medicines for inhalation general anesthesia (halogen-containing carbohydrates), narcotic analgesics, transfusion of large volumes of blood with citrate preservatives as anticoagulants, drugs that block neuromuscular transmission, increase neuromuscular blockade.
Store at a temperature not exceeding 30 ° C.
Keep out of the reach of children.
Shelf life is 2 years.