Persen

Pharmacological properties

persen, persen forte are herbal preparations with a mild sedative effect.

The combination of substances exhibits a mild sedative effect and is indicated for eliminating weak transient nervous tension (as a daily sedative for mental exertion, agitation, irritability).

Valerian has a sedative effect. It has a positive effect on well-being with symptoms of irritability, such as anxiety, agitation, and tension due to nervous overload. With insomnia, it contributes to faster falling asleep. Melissa also has a sedative and antispasmodic effect.

Peppermint is traditionally used in combination with valerian in sedatives.

Persen, Persen forte are used for neurosis, when the use of potent sedatives is not practical. Indications for use are determined solely on the basis of long-term experience.

Persen Cardio is a herbal preparation with a mild sedative effect.

The preparation contains dry extracts of Passiflora grass and leaves and flowers of hawthorn.

Preparations containing passiflora grass are used for temporary mental overload, agitation, and insomnia.

The extract of leaves and flowers of hawthorn increases cardiac conduction, improves coronary blood flow and vascular circulation, prevents cardiac arrhythmia and moderately reduces blood pressure.

The effectiveness of the combination of these plants is based on their traditional application. The effects of medicinal plants are mutually reinforcing. The combination exhibits moderate sedative and cardiotonic activity.

Persen Knight. The roots of valerian and passionflower have a calming effect in case of minor anxiety and tension caused by moderate stress, and also facilitate falling asleep.

Pharmacokinetics No data.

Indications

Persen, persen forte are prescribed for neurosis, accompanied by such symptoms:

• nervous agitation;
• anxiety;
• stress caused by stress;
• sleep disorders.

Persen Cardio: temporary mild forms of mental stress, anxiety, and irritability. Functional disorders of the heart and circulatory system associated with stress (for example, a feeling of increased heartbeat).

Persen Night is prescribed as a sleeping pill.

Application

Persen. adults and children over the age of 12 years: with mental stress, excited state or irritability, it is recommended to use 3 tablets 3 times a day; with insomnia - 3 tablets 1 hour before bedtime.

The tablets should be swallowed whole, washed down with water, regardless of the meal.

Persen Forte. Adults and children over the age of 12 years: with mental stress, agitation or irritability, it is recommended to use 2 capsules 2 times a day; with insomnia - 2 capsules 1 hour before bedtime.

Capsules should be swallowed whole, washed down with water, regardless of food intake.

The drug is characterized by a gradual manifestation of the action. To achieve the optimal treatment effect, it is recommended to use it for at least 14 days.

The duration of treatment is not limited. Even with prolonged use of the drug, addiction is not noted. After stopping treatment, there is no withdrawal syndrome.

If, after 14 days from the start of treatment, no improvement has occurred, you should consult your doctor.

Persen Cardio. Adults and children over 12 years old. The recommended dose is 1 capsule per day. If necessary, the dose can be increased to 1 capsule 2 times a day. The maximum daily dose is 2 capsules.

Capsules should be taken before meals (1 hour), washed down with water.

To achieve the optimal therapeutic effect, the drug should be taken for at least 6 weeks.If after 6 weeks of treatment the patients condition worsened or did not improve, you should consult a doctor.

Persen Knight. Adults and children over 12 years of age: 1 capsule 30 minutes before bedtime.

Swallow capsules whole, washed down with water, take regardless of food intake.

Persen Night is characterized by a gradual manifestation of the action. To achieve the optimal treatment effect, continuous use of the drug is recommended for at least 2 weeks. The duration of treatment is not limited. Even with prolonged use of the Persen drug, addiction was not noted. After discontinuation of treatment, there is no withdrawal syndrome.

If no improvement is noted within 14 days from the start of treatment, consult your doctor.

Contraindications

Hypersensitivity to valerian, lemon balm, peppermint, passionflower, hawthorn or other components of the drug. severe arterial hypotension, bradycardia, ba. depression or other conditions accompanied by inhibition of the central nervous system.

Side effects

From the alimentary canal: frequency cannot be estimated - nausea, cramping; exacerbation of heartburn is possible.

Very rarely, drowsiness, asthenic manifestations (weakness, decreased mood and performance, inhibition of emotional reactions), dizziness, depression are noted. If other side effects occur (for example, hypersensitivity reactions, including rash, itching, hives, redness and swelling of the skin), you should consult a doctor.

special instructions

In patients with severe hepatic impairment or who have experienced severe liver disease in the past, the drug should be used with caution.

Patients with gastroesophageal reflux (heartburn) should avoid the use of drugs containing peppermint leaves, as this can worsen their condition.

Patients with cholelithiasis or other diseases of the bile duct and gall bladder should be especially careful in prescribing preparations containing peppermint leaves.

The drug contains lactose, so it should not be used in patients with rare hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

1 tablet contains 14 mg of glucose and 67 mg of sucrose, 1 capsule contains 35 g of glucose, therefore, the drug should not be prescribed to patients with rare hereditary forms of fructose intolerance, sucrose-isomaltase deficiency or glucose-galactose malabsorption syndrome.

During the use of the drug should refrain from drinking alcoholic beverages.

Use during pregnancy and lactation. The effectiveness and safety of use during pregnancy and lactation have not been established, therefore, it is not recommended to use the drug during this period.

Children. Data on the use of the drug in children under the age of 12 years are not available, therefore it is not recommended to use it in this category of patients.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. The drug can affect the ability to drive vehicles and mechanisms, so during its use it is recommended to refrain from driving vehicles or other mechanisms until the individual sensitivity is clarified.

Interactions

Data on interactions with other drugs is limited. Before using the drug simultaneously with other medicines, you should consult your doctor.

No clinically significant interaction with active substances that are metabolized using CYP 2D6, CYP 3A4 / 5, CYP 1A2 or CYP 2E1 has been detected.

Concomitant use with synthetic sedatives (benzodiazepines) without consulting a doctor is not recommended.

With simultaneous use, it is possible to enhance the action of other sedatives and hypnotics, antispasmodic, analgesic, anxiolytic drugs, alcohol.

Overdose

Symptoms a dose of about 20 g of valerian roots, equivalent to about 103 tablets of persen and 42 capsules of persen forte, can cause minor symptoms such as fatigue, cramping, chest tightness, dizziness, hand tremor, dilated pupils. these symptoms disappear within 24 hours with an overdose of drugs containing valerian, headache, drowsiness, lethargy, general weakness, abdominal pain, nausea, decreased hearing and visual acuity, bradycardia / tachycardia, decreased concentration, increased sedation can also occur effect.

There are no reports of cases of overdose of lemon balm and peppermint leaves.

Symptomatic treatment (gastric lavage, intake of activated carbon).

Storage conditions

Persen: at a temperature not exceeding 25 ° C; persen forte, persen cardio, persen knight: at a temperature not exceeding 25 ° C in the original packaging. Keep out of the reach of children.