Palm fruit extract
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Pharmacological properties
in the etiology of benign prostatic hyperplasia, an important role is played by an increase in the formation of androgen dihydrotestosterone (DHT), which is the cause of prostate tissue growth by binding to androgen cytoplasmic receptors. DHT is formed from testosterone by activation of the 5-α-reductase enzyme. the effect of the extract from pollen palm fruits (serenoa repens) is associated with its antiandrogenic effect, namely, the blocking of the binding of DHT to the receptor, which leads to inhibition of the activity of 5-α-reductase. other factors that can also inhibit the growth of prostate tissue: inhibition of the binding of prolactin receptors and disruption of signal transmission processes, anti-inflammatory effect due to inhibition of the action of 5-lipoxygenase, inhibition of proliferation of the epithelium of the prostate gland, decongestant effect.
Prostamol Uno does not affect sexual function.
Benign prostatic hyperplasia may have the following symptoms: the need for more frequent urination, especially at night; weak or intermittent urination; feeling of an incompletely empty bladder; pain during urination; violation of sexual function.
Most of these symptoms are caused by an enlargement of the prostate gland as a result of constriction of the urethra (the formation through which urine leaves the bladder).
Prostamol Uno prevents a further increase in prostate tissue.
Pharmacokinetics After oral administration, the extract is rapidly absorbed and Cmax in blood plasma is achieved after 1.5 hours
Indications
Disorders of urination in benign prostatic hyperplasia of the i-ii stage and chronic prostatitis according to the alken classification.
Classification of benign prostatic hyperplasia by stages (according to Alken *):
| Stage | Title | Violation |
|---|---|---|
| I | Stage of irritation | Pollakiuria (day and night), nocturia, urinary retention, decreased urine flow, emptying of the bladder - complete |
| I I | Residual urine stage | Onset of decompensation, incomplete emptying of the bladder, residual urine |
| I I I | Stage de
compensation tions |
Urinary incontinence due to overflow of the bladder, acute urinary retention, stagnant kidneys, hydronephrosis, renal failure |
* Alken C.E. (1973) Leitfaden der Urologie. Stuttgart. Thieme, 180–182.
Application
Apply 1 soft capsule of Prostamol Uno daily at the same time. the soft capsule is swallowed whole after a meal with a sufficient amount of liquid. the duration of treatment depends on the type, severity and course of the disease and is not limited by time. regular daily use is especially important for the success of treatment. a decrease in the severity of disease symptoms can be expected only after 6 weeks of treatment. full effectiveness can be achieved no earlier than 3 months. if the manifestations of the symptoms of the disease do not decrease or, conversely, increase, then you should consult a doctor.
Contraindications
Hypersensitivity to the active substance or other auxiliary components of the drug.
Side effects
When analyzing side effects, the following values of the frequency of occurrence were taken as the basis: very often (≥1 / 10), often (≥1 / 100 to 1/10), sometimes (≥1 / 1000 to 1/100), rarely (≥1 / 10,000 to 1/1000), very rarely (1/10 000), the frequency is unknown (available information does not allow to evaluate this effect).
From the digestive tract: rarely - gastrointestinal disturbances, including discomfort from the digestive tract, nausea, pain in the stomach.
From the immune system: rarely - allergic reactions, such as skin rashes or swelling of the skin.
From the reproductive system: the frequency is unknown - reversible gynecomastia.
special instructions
If blood appears in the urine, urine is constantly leaking due to overflow of the bladder and with painful urges to urinate, which are combined with the sudden inability to urinate (acute urinary retention), you should immediately consult a doctor.
Patients are advised to consult a doctor or pharmacist before taking Prostamol Uno. It must be remembered that Prostamol Uno only alleviates the symptoms with enlargement of the prostate gland, but does not eliminate its enlargement. Therefore, patients should regularly consult a doctor to monitor the condition of the prostate gland.
Prostamol Uno should not be used for benign prostatic hyperplasia in the decompensation phase.
Use during pregnancy and lactation. The drug is used in men.
Children. The drug is used in adult men.
The ability to influence the reaction rate when driving vehicles or working with other mechanisms. The drug does not affect or has a slight effect on the ability to drive vehicles or work
246 Items
2020-07-30
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