Norgalax® [Docusate Sodium]
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Pharmacological properties
A tool that helps soften and facilitate the movement of feces, stimulates the defecation reflex. sodium docusate is an anionic surfactant that reduces the surface tension of the fluid in the colon. the effect is manifested at the level of fecal masses. Docusate sodium promotes water retention in the feces, which in turn increases their volume.
The onset of effect is 5–20 minutes after administration. Norgalax acts locally in the rectum. At the same time, minimal absorption of the drug by the intestinal mucosa and its entry into the systemic circulation during rectal administration is not excluded.
Indications
Symptomatic treatment for periodic constipation, when the use of an enema is necessary; preparation for endoscopic examination of the rectum.
Application
Apply rectally. the gel is injected into the rectum using a cannula tube (microclysters).
Before use, remove the cap. Insert the pointed part of the cannula tube into the rectum and squeeze out the contents of the entire tube under pressure. Remove the cannula without relieving pressure.
If necessary, a drop of gel can be used to lubricate the cannula.
Symptomatic treatment of constipation: 1 tube-cannula per day.
Preparation for endoscopic examination of the rectum: 1 tube-cannula 5–20 minutes before defecation.
Contraindications
Hypersensitivity to the components of the drug. intestinal obstruction, hemorrhoids, anal fissures, anal bleeding, inflammatory bowel disease.
Side effects
From the digestive tract: with prolonged treatment, a burning sensation may appear in the anus, pain in the rectal region, congestive proctitis, rectal bleeding can rarely develop. the presence of glycerin can lead to digestive disorders and diarrhea.
On the part of the hepatobiliary system: cases of hepatotoxicity have been identified with oral administration of docusate, especially in patients using other laxatives.
On the part of the skin: urticaria.
special instructions
It is not recommended to use the drug for a long time (in the absence of effect after 1-2 applications, it is necessary to reconsider the treatment tactics).
The use of the drug is unacceptable with ulcerative colitis.
Prolonged and improper use of a laxative can lead to a deficiency of potassium in the intestines.
During pregnancy and breastfeeding. It is not recommended to use the drug without a special doctors prescription.
Teratological studies in animals are not available.
With the use of sodium docusate in pregnant women, there were no violations of embryonic development and toxicity to the fetus.
Children. Do not use the drug in children under the age of 15 years. In children over 15 years of age, the drug is used as directed by a doctor.
The ability to influence the reaction rate when driving vehicles and working with other mechanisms.
Unknown
Interactions
The drug may enhance the absorption of other drugs. docusate sodium may enhance the hepatotoxicity of other drugs.
Overdose
May lead to excessive bowel movement, which is symptomatic.
Storage conditions
At a temperature not exceeding 25 ° C.
1389 Items
2020-07-30
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