Nitrofungin® [Chloronitrophenol]

Pharmacological properties

The drug nitrofungin is characterized by an antiseptic and disinfecting effect on gram-positive and gram-negative bacteria, mycobacteria, some fungi. active against the causative agent of dermatomycosis. the drug nitrofungin neo belongs to the group of derivatives of undecylenic acid, has a fungicidal and fungistatic effect. fungistatic effect is significantly expressed in relation to dermatophytes, facultative pathogenic fungi of the species scropulariopsis and yeast species of the candida species.

For external use, Nitrofungin Neo is not absorbed by the skin.

Phenol is absorbed in the digestive tract, skin, mucous membranes. Metabolized to phenyl glucuronide and phenyl sulfate. An insignificant part of phenol is oxidized to catecholamines and quinol. Metabolites are excreted in the urine, which in this case can acquire a light green color.

Indications

Treatment and prevention of dermatomycosis, especially interdigital / plantar foot dermatomycosis, epidermophytosis, trichophytosis, mycotic eczema; candidiasis and mixed skin infections, mycosis of the external auditory canal.

Application

Solution for external use nitrofungin: the drug can be used by adults and children over the age of 15 years. on the affected areas, the solution of the drug is applied pointwise or rubbed 2-3 times a day. duration of treatment — after the disappearance of signs of the disease, it is necessary to use the drug in the same way 1-2 times a week (with the goal of reliable cure) for 4 weeks. if these recommendations are not followed, a relapse of the disease is possible.

For the prevention of relapse, the drug is used 1-2 times a week.

As a rule, apply undiluted solution. In cases accompanied by severe local inflammation, as well as skin irritation, Nitrofungin solution diluted with water in a ratio of 1: 1 can be used.

Solution for external use and spray for external use Nitrofungin Neo. For adults and children over the age of 2 years, the solution of the drug is applied pointwise or rubbed 2-3 times a day; the spray is applied by spraying on the affected areas of the skin with an interval of 8-12 hours (preferably in the morning and evening) until the symptoms of the disease disappear. To prevent recurrence of the disease, it is necessary to continue the use of the drug and after the disappearance of symptoms in the same way 1-2 times a week for 4 weeks.

Usually undiluted solution is used only in cases of acute inflammatory process on the skin; if skin irritation occurs during treatment, the drug is diluted with water in a ratio of 1: 1.

Contraindications

Nitrofungin: Hypersensitivity to chlornitrophenol and other components of the drug, for children under the age of 15 years.

Nitrofungin Neo: a drug in the form of a solution, spray - for children under the age of 2 years.

Side effects

In some cases, skin irritation at the site of application of the drug (hyperemia, itching, swelling, burning sensation, skin rash) or increased sensitivity of the skin to direct sunlight (photosensitivity) may appear. in case of adverse reactions, a doctors consultation is necessary to determine the feasibility of further use of the drug.

special instructions

Use during pregnancy and lactation. there is no sufficient experience with the use of the drug during this period, so treatment is possible only after a careful determination of the appropriateness of its appointment. if within 3–7 days of use the therapeutic effect is not noted or the manifestations of the disease intensify, it is necessary to discontinue use and review treatment tactics. in case of skin irritation or skin rash at the place of application of the drug, its use should be discontinued. places treated with nitrofungin should be protected from direct sunlight.

The drug does not affect the ability to drive vehicles and work with complex mechanisms.

Interactions

There is no data.

Overdose

Cases of overdose with topical administration of nitrofungin are not described.

If phenol is accidentally swallowed, nausea, vomiting, excessive sweating, and diarrhea appear. After the excitement, which appears at the beginning, the patient may lose consciousness.

After swallowing phenol, the stomach should be washed with a solution containing olive or other vegetable oil to prevent further absorption. Assign the intake of activated carbon.

Storage conditions

In the dark place at a temperature of 10-25 ° c.