Neuromax

The effect of the drug is due to the action of its active components.

Neurotropic vitamins of group B have a beneficial effect on inflammatory and degenerative diseases of the nerves and the motor apparatus. They are used to eliminate deficient conditions, and in large doses they have an analgesic effect, improve blood circulation, normalize the functioning of the nervous system and the process of blood formation.

Vitamin B 1 (thiamine) is a very important active substance. In the body, vitamin 1 is phosphorylated to form biologically active thiamine diphosphate (cocarboxylase) and thiamine triphosphate (TTP).

Thiamine diphosphate as a coenzyme takes part in the process of carbohydrate metabolism, which are crucial in the metabolic processes of nerve tissue, affect the conduction of nerve impulses in synapses. With vitamin B 1 deficiency, metabolites accumulate in the tissues, primarily lactic and pyruvic acid, which leads to various pathological conditions and disorders of the nervous system.

Vitamin B 6 (pyridoxine) in phosphorylated form (pyridoxal-5-phosphate, PALP) is a coenzyme of a number of enzymes that interact in the general non-oxidative metabolism of amino acids. Through decarboxylation, they participate in the formation of physiologically active amines (adrenaline, histamine, serotonin, dopamine, tyramine), through transamination - to anabolic and catabolic metabolic processes (for example, glutamate-oxaloacetate transaminase, glutamate pyruvate transaminase, γ-aminobasic acid, a-aminasaminase) also to various processes of splitting and synthesis of amino acids. Vitamin B 6 acts on 4 different tryptophan metabolisms. In the process of hemoglobin synthesis, vitamin B 6 catalyzes the formation of a-amino-b-ketoadinic acid.

Vitamin B 12 (cyanocobalamin) is necessary for the processes of cellular metabolism. It affects the function of hematopoiesis (external antianemic factor), is involved in the formation of choline, methionine, creatinine, nucleic acids, and has an analgesic effect.

Pharmacokinetics After parenteral administration, thiamine is distributed in the body. Approximately 1 mg of thiamine breaks down daily. Metabolites are excreted in the urine. Dephosphorylation occurs in the kidneys. The biological half-life of thiamine is 0.35 hours. The accumulation of thiamine in the body does not occur due to the limited dissolution in fats.

Vitamin B 6 is phosphorylated and oxidized to pyridoxal-5-phosphate. In blood plasma, pyridoxal 5-phosphate and pyridoxal bind to albumin. The form being transported is pyridoxal. To pass through the cell membrane, pyridoxal-5-phosphate bound to albumin is hydrolyzed by alkaline phosphatase to pyridoxal.

Vitamin B 12 after parenteral administration forms transport protein complexes that are rapidly absorbed by the liver, bone marrow and other proliferative organs. Vitamin B 12 enters the bile and takes part in the intestinal-hepatic circulation. Vitamin B 12 passes through the placenta.

Indications

Neurological diseases of various origins: neuritis, neuralgia, polyneuropathy (diabetic, alcoholic), radicular syndrome, retrobulbar neuritis, damage to the facial nerve.

Contraindications

Hypersensitivity to the drug components acute cardiac conduction disorder acute form of decompensated heart failure.

Vitamin B 1 is contraindicated in allergic reactions.

Vitamin B 6 is contraindicated in case of peptic ulcer of the stomach and duodenum in the acute stage (since it is possible to increase the acidity of gastric juice).

Vitamin B 12 is contraindicated for use in erythremia, erythrocytosis, thromboembolism.

Lidocaine.Hypersensitivity to lidocaine or other amide local anesthetics, history of epileptiform seizures for lidocaine, severe bradycardia, severe arterial hypotension, cardiogenic shock, severe forms of chronic heart failure (II-III degree), sinus node weakness syndrome, Wolf-Parkinsons syndrome White, Adams-Stokes syndrome, AV (AV) block II and III degree, hypovolemia, severe impairment of liver / kidney function, porphyria, myasthenia gravis.

Dosage and administration

For an introduction.

Before using a medicine containing lidocaine, it is imperative to conduct a skin test for increased individual sensitivity to the drug, as evidenced by edema and redness of the injection site.

In severe (acute) cases, treatment should be started with 2 ml of the solution intramuscularly 1 time per day until acute symptoms are relieved. To continue treatment, prescribe 2 ml (1 injection) 2-3 times a week. The course of treatment lasts at least 1 month.

The injection should be performed in the upper outer quadrant of the gluteal muscle.

To maintain or continue the therapeutic course of injections or to prevent relapse, Neuromax, film-coated tablets are recommended.

Overdose

Vitamin B 1 has a wide therapeutic range. Very high doses (more than 10 g) exhibit a curariform effect, suppressing the conduction of nerve impulses.

Vitamin B 6 has a very low toxicity.

Excessive use of vitamin 6 in doses of more than 1 g per day for several months can lead to neurotoxic effects.

Neuropathies with ataxia and sensitivity disorders, cerebral seizures with changes in the EEG, as well as in some cases hypochromic anemia and seborrheic dermatitis have been described after the introduction of more than 2 g per day.

Vitamin B 12: after parenteral administration (in rare cases, after oral administration), doses of the drug are higher than recommended, allergic reactions, eczematous skin disorders and benign form of acne were observed.

With prolonged use in high doses, a violation of the activity of liver enzymes, pain in the heart, and hypercoagulation are possible.

Treatment: symptomatic therapy.

Lidocaine. Symptoms: psychomotor agitation, dizziness, general weakness, decreased blood pressure, tremor, visual impairment, tonic-clonic convulsions, coma, collapse, AV blockade, central nervous system depression, respiratory arrest are possible. The first symptoms of an overdose in healthy people occur when the concentration of lidocaine in the blood is more than 0.006 mg / kg, convulsions - at 0.01 mg / kg.

Treatment: cessation of drug administration, oxygen therapy, anticonvulsants, vasoconstrictors (norepinephrine, mesatone), with bradycardia - anticholinergics (0.5-1 mg of atropine). Perhaps intubation, mechanical ventilation, resuscitation. Dialysis is ineffective.

Structure

active ingredients: 1 ml of pyridoxine hydrochloride 50 mg, thiamine hydrochloride 50 mg, cyanocobalamin 0.5 mg

excipients: lidocaine hydrochloride, potassium hexacyanoferrate, sodium polyphosphate, benzyl alcohol, sodium hydroxide, water for injection.

Storage conditions

Store in the original packaging at a temperature of 2 ° to 8 ° C.

Keep out of the reach of children.

Shelf life is 2 years.