methionine

Pharmacological properties

methionine is an essential amino acid that is involved in transmethylation processes. has a lipotropic effect, promotes the synthesis of choline, phospholipids; participates in the synthesis of epinephrine, creatine; activates the action of hormones, vitamins, enzymes. possesses detoxifying properties due to the ability to methylate toxic products. reduces the concentration of chs in the blood and increases the content of phospholipids.

Pharmacokinetics Quickly absorbed in the intestines. As an irreplaceable sulfur-containing amino acid, it is used for protein synthesis and enters into various metabolic reactions - methylation, deamination, decarboxylation. With urine excreted in a small amount.

Indications

Treatment and prevention of diseases and toxic lesions of the liver: toxic hepatitis, alcoholic hepatopathy, cirrhosis, poisoning with arsenic preparations, chloroform, benzene and hepatotoxic substances.

The basis of combination therapy for chronic alcoholism, diabetes mellitus, for the treatment of dystrophy, which develops with protein deficiency after dysentery and infectious diseases, atherosclerosis, in severe surgery, burns.

Application

Adults are prescribed 500-1500 mg 3-4 times a day. single doses for children: 3-6 years - 250 mg, 7 years and older - 500 mg. the frequency of admission is 3-4 times a day.

The drug should be taken 30 minutes - 1 hour before meals. The course of treatment is 10-30 days or 10 days, with 10-day breaks between these courses.

Contraindications

Acute viral hepatitis, hepatic encephalopathy, severe liver failure, hypersensitivity to the drug.

Side effects

From the side of the immune system: allergic reactions.

From the digestive tract: nausea, vomiting.

special instructions

In acute and chronic renal failure, care must be taken in connection with the danger of hyperazotemia. the unbalanced use of methionine in high doses can lead to damage to liver cells.

Due to the unpleasant odor, children take the drug with sweet syrup, jelly.

The drug contains sugar, which should be considered for patients with diabetes mellitus.

Use during pregnancy and lactation. The use of the drug is possible if the benefits of the use for the mother outweighs the potential risk to the fetus / child.

Children. This dosage form is not used in children under the age of 3 years.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. No data available.

Interactions

The use of methionine in a balanced ratio with other amino acids prevents its toxic effect.

Overdose

Symptoms: arterial hypotension, tachycardia, disorientation are possible.

Treatment: gastric lavage, the appointment of activated carbon, symptomatic therapy.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.