Metadoxine

Pharmacological properties

Anti-alcohol, detoxification, hepatoprotective agent. activates liver enzymes involved in the metabolism of ethanol (alcohol dehydrogenase and acetaldehyde dehydrogenase), which helps to accelerate the process of excretion of ethanol and acetaldehyde from the body, reducing their toxic effects. increases the resistance of hepatocytes to lipid peroxidation products induced by exposure to various toxic agents, in particular ethanol. prevents the accumulation of fats in hepatocytes, which prevents the formation of fatty liver. prevents the formation of fibronectin and collagen, which inhibits the formation of cirrhosis.

It activates the choline and GABAergic neurotransmitter systems, resulting in improved thinking and short memory functions. Prevents the occurrence of motor excitation caused by ethanol. It has a nonspecific antidepressant and anxiolytic effect, reduces the craving for alcohol. Reduces the time to relieve withdrawal symptoms, reduces the mental and somatic manifestations of a hangover syndrome.

Metadoxine is rapidly absorbed in the digestive tract, has a high bioavailability (60–80%). Plasma protein binding is approximately 50%. It is metabolized in the liver with the formation of active metabolites - pyridine and pyrrolidone carboxylate. T_½ metadoxine when taken orally or with parenteral administration is 40-60 minutes. 45-50% of metadoxine is excreted in the urine within 24 hours, 35-50% - with feces within 96 hours.

Indications

Reducing the toxic effects of alcohol. acute alcohol intoxication (mild to moderate). alcohol withdrawal syndrome. chronic alcoholism. complex therapy of liver diseases, especially alcohol etiology.

Application

The drug is prescribed for adults inside.

To reduce the toxic effects of alcohol: 2 tablets 30-60 minutes before drinking alcohol or 1 tablet 30-60 minutes before drinking alcohol and 1 tablet within 30 minutes after drinking alcohol.

In case of acute alcohol intoxication of mild to moderate degree, alcohol withdrawal syndrome - 1 tablet 2 times a day 15-30 minutes before meals, the dose can be increased to 3 tablets per day. The course of therapy is 3-7 days, depending on the condition of the patient.

In the complex treatment of liver diseases and chronic alcoholism: 1 tablet 2 times a day 15-30 minutes before meals. The maximum daily dose is 3 tablets. The course of therapy is at least 90 days.

Contraindications

Hypersensitivity to any of the components of the drug.

Side effects

Allergic reactions.

special instructions

Metadoxine reduces the therapeutic effect of levodopa, so it should be used with caution in Parkinsons disease with levodopa therapy.

In conditions of severe alcohol intoxication, accompanied by loss of consciousness, indomitable vomiting, etc., the oral administration of drugs is impractical.

Use during pregnancy and lactation. Do not use.

Children. It should not be used in children due to lack of experience in this age group.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. Does not affect.

Interactions

With the combined use of metadoxine, due to the increased decarboxylation of levodopa, it reduces its therapeutic efficacy.

Overdose

No overdose of methadoxine has been reported.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.