Mesterolone

Pharmacological properties

Proviron compensates for androgen deficiency, the production of which gradually decreases with age. Thus, Proviron provides treatment for conditions caused by deficiency or complete absence of androgen production in the body. in recommended doses does not reduce spermatogenesis. the drug does not have hepatotoxicity.

After oral administration, Mesterolone is rapidly and almost completely absorbed in the dose range, which is 25-100 mg. The maximum concentration in serum is 3.1 ± 1.1 ng / ml, achieved 1.6 ± 0.6 hours after taking Proviron. Given this, the level of active substance in serum decreases with a final elimination half-life of 12–13 hours. 98% of mesterolone binds to blood plasma proteins, 40% of mesterolone binds to albumin and 58% to sex hormone-binding globulin (SHBG).

Mesterolone is rapidly metabolized. The metabolic clearance rate from serum is 4.4 ± 1.6 ml / min^–1/ kg^–1. It is escalated by the kidneys only in the form of metabolites. The main metabolite is 1α-methyl-androsterone, in conjugated form, accounting for 55–70% of the metabolites excreted by the kidneys. The ratio of glucuronides of the main metabolite to sulfates is about 12.1. Another metabolite is 1α-methyl-5α-androstan-3α, 17β-diol, which makes up about 3% of the metabolites that are excreted by the kidneys. No metabolic conversion to estrogen or corticoids was noted. About 80% of the dose of Mesterolone is excreted in the form of metabolites in the urine, and about 13% of the dose with feces. Within 7 days, 93% of the dose was detected in secretions, half of which was excreted in the urine for 24 years.

The absolute bioavailability of Mesterolone is about 3% of the oral dose.

Oral administration of a daily dose of Proviron leads to an increase in the level of a substance in the blood serum by approximately 30%.

Indications

Decrease in functional activity in middle and old age

Proviron eliminates or minimizes complaints caused by androgen deficiency, such as reduced ability to work, fatigue, memory and ability to concentrate, impaired libido and potency, irritability, sleep disturbances, depression and psycho-vegetative disorders.

Potency Disorder

Proviron eliminates potency disorders caused by androgen deficiency. If any other reasons play a role in the process of reducing potency, it is possible to prescribe Proviron as an additional agent in complex therapy.

Hypogonadism

Proviron has a stimulating effect on the growth, development and functioning of androgen-dependent target organs. In the case of androgen deficiency, even in the prepubertal period, Proviron promotes the development of secondary sexual characteristics in men. With the help of Proviron, the symptoms of androgen deficiency are eliminated with a decrease in the function of the genital glands after reaching the age of puberty.

Male infertility

Infertility can be caused by oligozoospermia and insufficient secretion by Leydig cells. Using Proviron, you can increase or normalize the quantity and quality of sperm, as well as the concentration of fructose in the ejaculate, which increases the likelihood of fertilization.

Application

Tablets are taken whole without chewing, with a sufficient amount of liquid.

The following treatment regimens are recommended:

In case of decreased functional activity and impaired potency

At the beginning of treatment:

1 tablet 3 times a day Proviron. After achieving improvement in the patients condition, you can try to reduce this dose.

Further treatment:

1 tablet of Proviron 1-2 times a day. Depending on the type and intensity of dysfunction or complaints, an individual dose should be selected for further treatment.Continued treatment for several months is recommended.

In case of hypogonadism, prolonged treatment is necessary:

In order to stimulate the development of secondary sexual characteristics, take 1-2 tablets of Proviron 3 times a day for several months. As a maintenance dose, it is enough to take 1 tablet of the drug 2-3 times a day.

In case of infertility, to increase the quantity and quality of sperm:

Throughout the full cycle of spermatogenesis, that is, for approximately 90 days, take 1 tablet of Proviron 2-3 times a day. If necessary, the treatment cycle should be repeated after a break of several weeks. To increase the concentration of fructose in the ejaculate in case of insufficiency of Leydig cells in the post-puberty period: for several months, take 1 tablet of Proviron 2 times a day.

Contraindications

Cancer of the prostate gland, a tumor of the liver at a given time or in history. hypersensitivity to the active substance or any component of the drug.

Side effects

In some cases, a frequent and too long erection can be observed, while reducing the dose or stopping treatment in order to avoid complications due to a prolonged erection.

special instructions

Androgens should not be taken by healthy individuals to strengthen muscles or increase overall physical abilities.

Proviron is intended exclusively for use by male patients.

For the purpose of prevention, periodic examination of the prostate gland is recommended.

Caution for use

After taking the hormonal substances that make up the Proviron drug, the formation of benign, and even less often, malignant liver tumors is very rare. In some cases, intra-abdominal bleeding caused by such tumors posed a threat to life. If a man who uses Proviron has severe pain in the upper abdomen, an enlarged liver, or there are signs of intra-abdominal bleeding, the differential diagnosis should take into account the likelihood of a liver tumor.

Interactions

Not described.

Overdose

The results of studies of acute toxicity of the drug indicate that the drug Proviron can be regarded as non-toxic. even with a random single dose, which is several times higher than the therapeutic, there is no risk of toxicity.

With an overdose of the drug, along with increased sexual arousal, dizziness, nausea, water and salt retention in the body may occur. These phenomena pass independently after a dose reduction or drug withdrawal.

Storage conditions

At a temperature not exceeding 30 ° C.