Magnesium, Pyridoxine Hydrochloride

Pharmacological properties

The combined preparation contains magnesium and vitamin b6.

Magnesium is a mineral that affects almost all body functions. His most important actions are: participation in energy processes. ATP, which is a chemical source of energy, can enter the process of energy formation only in the form of magnesium salt. Magnesium is also a cofactor of the enzyme that catalyzes this process; it is a structural element for the formation of bones and teeth; regulates the permeability of cell membranes and organelles of the cell (including mitochondrial), which leads to increased elasticity of the walls of blood vessels, improve contractility of the heart muscle, reduce the risk of arrhythmia; takes part in the activities of more than 300 enzymes; protects cells from excessive calcium intake; is a calcium antagonist, and as such plays a regulatory role in a number of biological processes; indirectly increases the activity of the antioxidant defense system; reduces the risk of convulsive conditions (eclampsia, preeclampsia), especially during pregnancy; possesses antithrombotic activity.

Vitamin B₆ (pyridoxine) - as a coenzyme, it participates in protein metabolism (transamination, decarboxylation, deamination, resulfurization, formation of nicotinic acid from tryptophan, hemoglobin synthesis); as a coenzyme takes part in the metabolism of carbohydrates and fatty acids (conversion of glycogen to glucose-1-phosphate, conversion of linoleic acid to arachidonic acid, etc.).

Magnesium is actively absorbed in the upper part of the small intestine. The degree of absorption is 30-40% of the oral dose. Magnesium citrate and magnesium oxide have a good absorption profile. Special transport through the cytoplasmic and mitochondrial membranes is characteristic. In regulating internal Mg levels²⁺ (cytoplasmic and mitochondrial) the main element is the enzyme Ca⁺⁺-Mg⁺⁺adenosine triphosphatase. Usually the movement of calcium and magnesium is the opposite. On average in an adult, the Mg content²⁺ is 1000 mmol. About 50% of this amount is included in bone tissue (30% of this amount is subject to change). Intracellular and extracellular magnesium account for 45 and 5%, respectively. In the blood plasma, the concentration of magnesium ranges from 0.75 to 1.20 mmol / L, with 30% of the plasma magnesium being bound to proteins. It interacts to a large extent with calcium, less with potassium.

Most of the magnesium included in bones and teeth is not replaced, but magnesium is also deposited in muscle tissue, kidneys, liver and heart.

The main route of magnesium excretion from the body is through the kidneys (range 1–250 mmol), but they also take part in maintaining magnesium in the body by reabsorbing the main amount in the proximal tubules (in the ascending segment of the Henle loop), with excretion being approximately 3-5% filtered magnesium.

Different forms of vitamin B₆ absorbed by passive diffusion, mainly in the small and ileum. In the blood, the main form of vitamin B₆ is pyridoxalphosphate bound to blood plasma proteins (albumin), only an insignificant part of it is in the form of free pyridoxal. Pyridoxal is more able to penetrate cell membranes than its phosphate form. Pyridoxal, having passed through the cell membrane, is again phosphorylated with the participation of kinase, and thus, the main tissue form is pyridoxalphosphate. Vitamin A is deposited in two forms: partly in the form of pyridoxalphosphate, partly in the form of pyridoxamine phosphate. In a protein-bound state, a larger amount can be detected in the liver, kidneys, brain, spleen, and skeletal muscle.

It is excreted in the urine in the form of various metabolites, the main of which is 4-pyridoxic acid.

The metabolism of all components is significantly reduced with insufficient functioning of the kidneys.

Indications

Magnesium deficiency treatment. prevention of magnesium deficiency in conditions accompanied by an increased need for it (during pregnancy and lactation, increased physical activity).

Replenishment of the proper level of magnesium in the body with a primary deficiency caused by a reduced intake of magnesium with food (restrictive diets), as well as with a secondary magnesium deficiency caused by either reduced absorption (pancreatic insufficiency, Crohns disease, ulcerative colitis), or increased magnesium loss ( diarrhea, increased excretion with urine, burns), as well as with secondary magnesium deficiency caused by certain types of drug therapy (some antibiotics, immunosuppressive drugs, di YETİK and chemotherapy drugs). As a preventive measure for chronic physical and mental fatigue, irritability, stress, depression, sleep disturbance, headache, myalgia, intense physical and mental stress.

Supplementary therapy for the prevention of magnesium deficiency in: the aging process, diseases with a carbohydrate metabolism disorder characterized by insulin resistance (obesity, decreased glucose tolerance, non-insulin-dependent diabetes mellitus), with essential hypertension, ischemic heart disease, some types of cardiac arrhythmias, stroke.

Application

The usual dose for adults is 1 tablet per day.

Children aged 2 years – 10 years are prescribed ½ tablets once a day (if necessary, the tablet can be ground). Children over the age of 10 are prescribed 1 tablet 1 time per day.

During pregnancy and lactation, it is possible to take the drug in the usual daily dose for adults.

The tablets should be taken after meals and washed down with plenty of water. The duration of treatment is determined individually.

Contraindications

Hypersensitivity to the components of the drug, the simultaneous use of other drugs containing magnesium, hypermagnesemia, severe renal failure, children under the age of 2 years.

Side effects

When using the drug very rarely (in cases of exceeding the recommended dose), diarrhea or pain in the abdomen is possible. in such cases, the use of the drug must be discontinued.

special instructions

The drug does not affect the ability to drive vehicles and work with potentially dangerous mechanisms.

Interactions

Magnesium reduces the degree of absorption of certain drugs for oral use (tetracyclines, calcium-containing drugs, iron compounds, bisphosphonates), so the interval between taking these drugs and the drug using magnesium plus B6 should be at least 3 hours.

Potassium-sparing diuretics can increase tubular reabsorption of magnesium, so they can be taken only under the supervision of a doctor. Magnesium can reduce digitalis glycosides in digital blood plasma, therefore, patients taking digitalis drugs, Beresh Magnesium plus B₆ can be prescribed only under the constant supervision of a doctor.

Vitamin B₆ only under the supervision of a doctor can be taken simultaneously with drugs containing levodopa (their effectiveness may decrease).

Overdose

Overdose symptoms can occur only with prolonged use of the drug in doses many times higher than the recommended daily dose. symptoms of possible intoxication: weakness, nausea, vomiting, bradycardia, hyporeflexia, paresthesia and, in a severe case, a delusional state. as an antidote, calcium compounds can be used, 100-200 mg iv for 5-10 minutes, in addition, hemodialysis can be performed.

Storage conditions

In a dry place at a temperature of 15-25 ° C.