Lisobact

Pharmacological properties

Lisobact is an antiseptic that is used for local treatment in dentistry and otolaryngology.

Lysozyme is a mucopolysaccharide, effective against gram-positive bacteria, due to the ability to convert insoluble polysaccharides of the cell membrane into soluble mucopeptides. Also effective against gram-negative bacteria, viruses and fungi. Lysozyme has a local anti-inflammatory effect and increases the nonspecific resistance of the body.

Pyridoxine has a protective effect on the mucous membrane of the oral cavity and exhibits anti-aphthous effect.

Pyridoxine is rapidly absorbed in the digestive tract, its biologically active form binds to blood plasma proteins and is deposited in the muscles, liver, central nervous system and other body tissues. Pyridoxine crosses the placental barrier and is excreted in breast milk. It is metabolized in the liver and excreted in the urine in the form of 4-pyridoxic acid.

After metabolic disintegration, lysozyme is excreted in the urine.

Indications

Infectious and inflammatory diseases of the oral mucosa and throat: Vincent’s tonsillitis, acute and chronic tonsillitis, pharyngitis, stomatitis, aphthous stomatitis, herpetic stomatitis, erosion of the oral mucosa of various etiologies; in the postoperative period (after tonsillectomy, cryodestruction of the tonsils).

Application

The tablets should be dissolved like lozenges, holding them as long as possible in the oral cavity. children aged 3–7 years: dissolve 1 tablet 3 times a day; 7-12 years: 1 tablet 4 times a day. adults and children over the age of 12 years: 2 tablets 3-4 times a day. treatment duration is 8 days. if necessary, after consulting a doctor, treatment can be extended.

Contraindications

Hypersensitivity to any component of the drug.

Side effects

In some cases, allergic reactions are possible.

From the immune system: anaphylactic shock, anaphylactic reactions, Quinckes edema.

On the part of the skin: urticaria, rash, itching, photosensitivity.

special instructions

If an allergic reaction to the drug occurs, its use should be discontinued. Lysobact is intended for resorption, do not swallow the tablet for resorption. the drug contains lactose, therefore, patients with a rare hereditary form of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.

During pregnancy and breastfeeding. Lisobact can be used during pregnancy and lactation.

Children. The drug is not used in children under the age of 3 years.

It does not affect the reaction rate when driving vehicles and working with other mechanisms.

Interactions

The therapeutic effect of antibacterial drugs has been enhanced with simultaneous use with lisobact. lysozyme increases the effectiveness of antibacterial drugs such as penicillin, chloramphenicol.

Isoniazid, penicillamine, pyrazinamide, hydralazine, immunosuppressants, estrogens (including oral contraceptives containing estrogens) can increase the need for pyridoxine, since they act as antagonists of the latter or increase its renal excretion.

Pyridoxine hydrochloride enhances the decarboxylation of levodopa in peripheral tissues and reduces its effectiveness in the treatment of Parkinsons disease.

Overdose

Not described. overdose symptoms (peripheral neuropathy, myodystrophy, increased manifestations of adverse reactions) can occur after the use of pyridoxine in high doses, significantly higher than therapeutic.

Storage conditions

At a temperature not exceeding 25 ° C.