Hesperedin, Diosmin

Pharmacological properties

Avenue has a venotonic and angioprotective effect, increases venous tone, reduces the extensibility of veins and venostasis, improves microcirculation, reduces the permeability of capillaries and increases their resistance, improves lymphatic drainage, increasing lymphatic outflow.

The drug also reduces the interaction of leukocytes and endothelium, the adhesion of leukocytes in postcapillary venules. This reduces the damaging effect of inflammatory mediators on the walls of the veins and valve leaflets.

Pharmacokinetics T_½ is 11 hours

Excretion of the active substance is carried out mainly through the intestines. With urine, an average of 14% of the applied dose is excreted.

Indications

Symptomatic treatment of venolymphatic insufficiency (heaviness in the legs, pain, swelling). symptomatic treatment of hemorrhoids.

Application

For oral use. appointed by adults.

Treatment of venolymphatic insufficiency (symptoms: swelling, pain, heaviness in the legs, night cramps, trophic ulcers, lymphedema).

The recommended dose is 2 tablets per day: 1 tablet in the afternoon and 1 tablet in the evening, with meals. After a week of use, you can take 2 tablets per day at the same time with food.

Treatment of chronic hemorrhoids. 2 tablets per day (in two divided doses) with meals. After a week of use, you can take 2 tablets per day once with meals.

Treatment of acute hemorrhoids. 6 tablets per day for 4 days, then 4 tablets per day for the next 3 days. Apply with food. The daily number of tablets is divided into 2-3 doses.

A course of treatment. The duration of treatment depends on the indications for use and the course of the disease. The average duration of treatment is 2-3 months.

Children. There are no data on the use of Avenue in children.

Contraindications

Hypersensitivity to the active substance or any of the excipients.

Side effects

From the nervous system: dizziness, headache, malaise;

from the gastrointestinal tract: diarrhea, dyspepsia, nausea, vomiting, colitis;

on the part of the skin and subcutaneous tissues: rash, itching, urticaria, isolated swelling of the face, lips, eyelids, Quinckes edema.

special instructions

The use of this drug in acute hemorrhoids does not replace specific treatment and does not interfere with therapy for other proctologic diseases. if within a short course of treatment the symptoms do not disappear quickly, a proctological examination should be carried out and therapy should be reviewed.

In case of impaired venous circulation, a more effective treatment is provided by a combination of therapy in compliance with such lifestyle recommendations:

• avoid prolonged exposure to the sun, prolonged stay on the legs, overweight;
• walking and in some cases wearing special stockings to improve blood circulation.

Use during pregnancy and lactation. In pregnant women, the drug should be used with caution. Before use, consult your doctor.

Studies have not revealed teratogenic effects of the drug, no side effects have been reported.

Due to the lack of data on the penetration of the drug into breast milk, the use of the drug during lactation should be avoided.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms. The drug does not affect the ability to drive vehicles and work with various mechanisms. If there are signs of side effects of the drug (see ADVERSE EFFECTS), you must be careful.

Interactions

No interaction studies have been conducted. however, there is extensive post-registration experience with diosmin, and no interactions with other drugs have been reported to date.

Overdose

No cases of overdose have been reported.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.