Glutalit® [Lithium hydroglutamate]

Pharmacological properties

Normotymic drug. lithium ions alter the transport of sodium ions in neurons, increase intracellular deamination of norepinephrine, which reduces its free amount, and increase the sensitivity of neurons to dopamine. glutamate in significant quantities is located in the brain tissue and takes part in the processes of transamination and binding of ammonia, which significantly increases the therapeutic effect of lithium ions. as a result, the drug has a pronounced normotimic effect.

It is well absorbed from the small intestine and evenly distributed in the body. Penetrates through the BBB and the placenta. It is determined in breast milk. Excreted by the kidneys by filtration. About ⁴/₅ its reabsorbed. The half-life is approximately 24 hours. With a decrease in the intake of sodium ions in the body, an increase in the half-life of lithium is observed.

Indications

Manic-depressive psychosis, periodic forms of schizophrenia, depression in old age, treatment of affective disorders in patients with chronic alcoholism.

Application

Adults are recommended to prescribe in an initial and maintenance dose 1 capsule 2 times a day in the morning and in the evening after meals, drinking 1/2 glass of water. in order to enhance the therapeutic effect, the dose can be increased; the maximum daily dose is 2.1 g. after the therapeutic effect is achieved, the dose is reduced to a maintenance one. mandatory periodic determination of the concentration of lithium in blood plasma; the maximum permissible concentration is 1.6 mol / l.

Contraindications

Impaired renal excretory function, diseases of the cardiovascular system in the decompensation phase and with impaired myocardial conduction, pregnancy and lactation, thyroid dysfunction.

Side effects

It is usually well tolerated, in some cases a slight headache and nausea are possible. when taken in toxic doses, drowsiness, diarrhea, vomiting, dizziness, tremor, ataxia, blurred visual perception, tinnitus may occur.

special instructions

Glutalitis treatment should be carried out under the control of serum lithium concentration and under the condition of a normal state of excretory function of the liver and kidneys. the drug must be used carefully with epilepsy and with a deficiency of sodium and water in the body (the use of diuretics, intense sweating, diarrhea, hyponatremia).

Interactions

The simultaneous use of glutalitis with diuretics or NSAIDs can lead to an increase in the concentration of lithium in blood serum.

Overdose

In acute or chronic lithium poisoning, sodium bicarbonate and forced diuresis are prescribed using aminophylline, acetazolamide, etc., hemo- and peritonial dialysis. when exceeding the maximum allowable concentration of lithium in the blood (1.6 mol / l), muscle weakness, tremors, polyuria, thirst, and heart rhythm disturbance can be observed.

Storage conditions

In a dry, dark place at temperatures up to 25 ° C.