Escuvit

Pharmacological properties

Escuvit - venotonic, angioprotective, decongestant, anti-inflammatory agent. The mechanism of action of escin is due to the stabilization of lysosomal membranes, inhibition of the release of autolytic cellular enzymes. the drug reduces the permeability and fragility of capillaries, preventing transcapillary filtration of low molecular weight proteins, electrolytes and water into the intercellular space, increases the tone of the venous wall, eliminates venous congestion (especially in the lower extremities), reduces peripheral edema, trophic damage to the walls of venous vessels, a feeling of heaviness in the legs, fatigue, tension, itching, pain.

Pharmacokinetics When ingested, escin is rapidly adsorbed, mainly in the duodenum. It undergoes a pronounced effect of the first passage through the liver. In tissue fluid and blood plasma, escin binds to proteins (about 84%) and cholesterol. Metabolized in the liver. The drug is excreted in the urine and bile in the form of metabolites.

Indications

Chronic venous insufficiency of venous and post-thrombotic genesis and its complications. diseases associated with functional disorders of the blood supply, for example, congestion, inflammation of the veins, varicose veins, edema and hemorrhoids.

Application

Tablets: for adults, 1 tablet (40 mg) is prescribed 3 times a day. tablets are taken after meals with plenty of water.

The duration of treatment is determined by the doctor individually, depending on the severity of the disease and the clinical effectiveness of the drug. The course of treatment is usually 3 months, if necessary, the duration of the course can be increased.

Drops: inside. Adults and children over the age of 12 are advised to take 10–20 drops 3 times a day before meals with a small amount of water. Shake before use. The course of treatment is usually from 2 weeks to 2-3 months.

Contraindications

Hypersensitivity to the components of the drug; severe kidney disease, chronic kidney disease.

Side effects

From the nervous system: headache, dizziness.

On the part of the skin, subcutaneous tissue / immune system: hypersensitivity reactions, including urticaria, rash, itching, sensation of heat, angioedema.

From the cardiovascular system: tachycardia, heart palpitations, arterial hypotension.

From the digestive tract: dyspeptic symptoms, pain in the epigastric region, nausea, diarrhea, vomiting.

As a rule, the described side effects quickly disappear after discontinuation of the drug.

If other adverse reactions occur, consult your doctor.

special instructions

When using the drug, it is necessary to monitor renal function.

The drug in the form of tablets cannot be used in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

In case of sudden onset of unusual serious manifestations, especially in only one lower limb, such as edema, discoloration of the skin, a feeling of tension or heat, pain, the patient should immediately consult a doctor, since these signs may be symptoms of thrombosis of the veins of the lower extremities caused by a blood clot .

In case of dyspeptic phenomena, it is recommended that you switch to taking the drug with food.

Use during pregnancy and lactation. The drug is not recommended for use during pregnancy and lactation due to insufficient data on the safety of its use during this period.

Children. There is no experience with children. The drug is not prescribed for children.

The ability to influence the reaction rate when driving vehicles or working with other mechanisms.Does not affect the reaction rate when driving vehicles or mechanisms. For the drug in the form of drops, it has not been studied, but in connection with the content of 96% alcohol, it should be used with caution when driving vehicles and working with potentially dangerous mechanisms.

Interactions

The effect of the drug is reduced by sulfur-containing solutions for iv administration (sodium thiosulfate). enhances the effect of anticoagulants, therefore, if necessary, simultaneous administration with anticoagulants, the dose of the latter should be reduced (under the control of the prothrombin index).

The drug should not be taken simultaneously with aminoglycoside antibiotics in order to avoid an increase in their nephrotoxic effect. With the simultaneous use of cephalosporin antibiotics, the binding of escin to blood plasma proteins is difficult, as a result of which it is possible to increase the concentration of free escin in the blood and the risk of side effects.

The action of thiamine is inactivated by fluorouracil, since the latter competitively inhibits thiamine phosphorylation to thiamine pyrophosphate.

Overdose

If the recommended doses are exceeded, an increase in the severity of side effects, nephrotoxic reactions, arterial hypotension, and thrombosis are possible.

Treatment: drug withdrawal, symptomatic therapy. There is no specific antidote.

Storage conditions

In the original packaging at a temperature not exceeding 25 ° C.