Curiosin® [Zinc Hyaluronate]

Pharmacological properties

hyaluronic acid and other proteoglycan molecules stabilize the intercellular substance of connective tissue. zinc ions block the activity of lipase p. acnes, and also have an antibacterial property. kuriosin gel reduces the formation of acne and the severity of the inflammatory process. local application of the gel kuriozin makes up for the increased need for hyaluronic acid in the tissues.

Hyaluronic acid with water molecules forms a dispersion matrix that replaces a tissue defect, forms a natural support for cells, increases the activity of granulocytes and macrophages and enhances fibroblast proliferation and angiogenesis. Zinc hyaluronate in comparison with sodium hyaluronate has a bacteriostatic effect on a number of microorganisms.

Pharmacokinetics Regarding the pharmacokinetics of exogenous hyaluronic acid, data are insufficient.

According to the literature, the concentration of hyaluronic acid in healthy volunteers is in the range of 10-100 μg / l. An increased level of hyaluronic acid in blood plasma was detected in healthy (studied) elderly patients in the morning in the presence of impaired liver function. Hyaluronic acid is quickly removed from the blood plasma, splitting into components with a low molecular weight occurs in the liver. After iv administration of T_½ is 2.5–5.5 minutes Hyaluronic acid is almost not excreted in the urine (1%). According to data from 22 healthy volunteers, the clearance of hyaluronic acid is 320 mcg in 24 hours.

Indications

Local treatment for all forms of mild to moderate acne, including comedones and papular-pustular acne.

Application

The drug is intended for external use.

2 times a day should be applied with a thin layer to the affected area after hygienic cleaning of the skin.

The drug is absorbed after a few minutes, so there is no need for a bandage.

Contraindications

Hypersensitivity to any of the components of the drug.

Side effects

At the beginning of the course of treatment, a burning sensation, flushing of the skin are possible, which gradually disappear during therapy. with dry skin, a feeling of tension and stretching may occur.

Perhaps the development of allergic reactions in individuals with increased sensitivity to the components of the drug.

On the part of the skin and subcutaneous tissues: often (≥1 / 100–1 / 10) - burning sensation of the skin.

special instructions

The drug does not cause photosensitization, does not stain skin and underwear.

During pregnancy and breastfeeding. There is no data on the use of the drug during pregnancy and lactation.

Children. There is no data on the use of the drug in children under the age of 14 years. The method of use of the drug Curiosin gel in children over the age of 14 is the same as in adults.

The ability to influence the reaction rate when driving vehicles and working with other mechanisms. The drug does not affect the ability to drive vehicles and work with other mechanisms.

Interactions

To date, unknown.

Overdose

To date, unknown.

Storage conditions

At a temperature not exceeding 30 ° C.