Cefasel® [Sodium Selenate]

Pharmacological properties

Selenium is one of the most important trace elements. in human blood plasma, selenium binds to glutathione peroxidase and a transport protein known as selenoprotein p in the form of the amino acid selenocysteine. selenium-containing glutathione peroxidase is a component of the antioxidant defense system of cells.

An inverse relationship is known between the level of selenium in the blood plasma and the likelihood of developing diseases of the cardiovascular system (cardiomyopathy, arteriosclerosis, myocardial infarction), as well as cancer. In patients with renal failure and gastrointestinal diseases, a decrease in the level of selenium in the blood plasma is noted.

When taken orally, sodium selenite is absorbed mainly in the duodenum. In the blood, selenium is absorbed by red blood cells and restored by enzymes to hydrogen selenium. Hydrogen selenium is the central accumulator of selenium for excretion from the body and for the formation of complexes with selenoprotein. Excess hydrogen selenide is metabolized by methyl selenol and dimethyl selenide to trimethyl selenium ions, the main excretion product. The total amount of selenium in the human body is 4–20 mg. The removal of selenium from the human body depends on the dose consumed and the level of selenium in the body. Selenium is excreted in feces, urine, and also through the lungs in the form of trimethylselen ions and other metabolites.

Indications

An established deficiency of selenium in the body that occurs in cases of digestive / malabsorption disorders and malnutrition (for example, general parenteral nutrition), which cannot be compensated by diet.

Application

Tablets must be taken whole without chewing, drinking with a small amount of liquid, after eating. unless otherwise indicated, the dose is 100 micrograms of selenium per day. this dose can be increased for a short period to 300 micrograms of selenium. treatment is carried out until the normal level of selenium in the blood plasma is restored - 80–120 ng / ml, in whole blood - 100–140 ng / ml.

Contraindications

Hypersensitivity to the components of the drug, intoxication due to poisoning with selenium.

Side effects

Hypersensitivity reactions are possible.

special instructions

Patients with rare inherited diseases such as fructose intolerance, glucose-galactose malabsorption, or sucrose-isomaltase deficiency should not take this drug.

If you skip taking the drug, you must continue to take it according to the recommendations and you should not take a double dose to compensate for the missed one. Even after prolonged use of the drug, addiction and withdrawal syndrome do not develop.

During pregnancy and breastfeeding. Provided that the drug is taken as directed, there are no restrictions on the use during pregnancy and lactation.

Children. Selenium is not contraindicated in children, but this dosage form is not used in children.

It does not affect the reaction rate when driving vehicles or working with other mechanisms.

Interactions

It is necessary to avoid taking cefasel simultaneously with ascorbic acid, since this leads to a decrease in the bioavailability of selenium.

Overdose

Symptoms of acute overdose include garlic breath, fatigue, nausea, diarrhea, and abdominal pain. in case of chronic overdose, there are violations of the growth of nails and hair, as well as peripheral polyneuropathies. in cases of acute overdose, the stomach should be washed and symptomatic therapy should be carried out. in cases of chronic overdose, the dose of the drug should be reduced.

Storage conditions

It does not require special storage conditions.