Candiderm

Pharmacological properties

Candiderm is a combined drug that has antibacterial and anti-inflammatory effects for external use. the pharmacological effect of candida is due to the properties of clotrimazole, gentamicin sulfate and beclomethasone dipropionate, which are part of it. Clotrimazole is a broad-spectrum antifungal agent from the group of imidazole derivatives. dermatophytes, yeast fungi (genus candida, torulopsis glabarata, rhodotorula), mold fungi, as well as pathogens pityriasis versicolor (colorful lichen) and erythrasma are sensitive to it. in addition, clotrimazole has an antimicrobial effect against gram-positive (staphylococci, streptococci) and gram-negative bacteria (bacteroides, gardnerella vaginalis), as well as against trichomonas vaginalis, malasseria furfur, corinebacterium minussimum. the effect of clotrimazole is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi. as a result, the structure and properties of cell membranes change, cell lysis is noted.

Gentamicin sulfate is an antibiotic of the aminoglycoside group. It has a wide spectrum of activity against most pathogens that cause skin diseases.

Beclomethasone dipropionate - a synthetic analogue of the hormones of the adrenal cortex, has anti-inflammatory, anti-allergic, antiexudative and antipruritic effect.

Pharmacokinetics Special studies of the pharmacokinetics of the drug have not been conducted.

Clotrimazole practically does not enter the systemic circulation with local (cutaneous) use.

When applied topically, gentamicin sulfate is not absorbed through healthy skin. From large areas of damaged, burned or covered with granulation tissue skin is absorbed quickly.

Beclomethasone dipropionate, like other corticosteroids, penetrates through healthy skin into the systemic circulation. In inflammatory processes and other skin diseases, the absorption of local corticosteroids is significantly increased. When applied topically, the pharmacokinetic features are similar to those for systemic use. It binds to plasma proteins, is metabolized in the liver.

Indications

Candiderm is intended for topical use in infectious-inflammatory and allergic skin diseases accompanied by a secondary bacterial and fungal infection.

Application

Outwardly 2-3 times a day. Before use, it is necessary to rinse and dry the affected area. after that, completely cover the affected area with a thin layer of cream. on the hairy areas of the body before applying the cream, it is necessary to spread the hair to achieve direct contact with the affected area.

Usually, the manifestations of the disease disappear within 2-4 weeks from the start of the drug, however, treatment should be continued for several days after the disappearance of any manifestations of the disease.

Contraindications

Cutaneous tuberculosis, chickenpox, herpes simplex, measles, vaccination period, syphilitic skin lesions. increased individual sensitivity to any component of the drug. During pregnancy and breastfeeding.

Side effects

Burning sensation, dry skin, folliculitis, hypertrichosis, acne-like rashes, redness of the skin, vesicles, exfoliation of the epidermis, tingling sensation, swelling, itching, hives.

special instructions

The drug is intended for use only in dermatological practice. prolonged use of the drug can cause excessive growth of insensitive microorganisms. in this case, treatment should be discontinued and appropriate treatment measures taken. the systemic absorption of beclomethasone dipropionate and gentamicin can significantly increase when using the drug on large areas of the skin, especially when applied to damaged, burned or covered with granulation tissue skin.

In this regard, it is necessary to avoid the use of the drug on open wounds or damaged areas of the skin.

It is not recommended to use Candiderm with occlusive dressings.

Influence on the ability to drive vehicles and mechanisms. Candiderm does not affect the ability to drive vehicles and mechanisms.

Interactions

Missing.

Overdose

Acute overdose with topical administration of candida is unlikely. however, topical application on large areas of the skin can lead to systemic absorption of beclomethasone and gentamicin.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 ° C.