Amikacin

Amikacid solution is indicated for the treatment of infections caused by strains of microorganisms resistant to other aminoglycosides that are sensitive to amikacin.

Structure

Active substance: amikacin;

1 ml of amikacin sulfate is equivalent to amikacin - 250 mg;

Excipients: sodium, sodium metabisulfite (E 223), sulfuric acid, water for injection.

Contraindications

• renal failure;
• auditory nerve neuritis;
• hypersensitivity to amikacin or to any other antibiotic with the aminoglycoside groups and their derivatives;
• hypersensitivity to any of the excipients that make up the drug;
• myasthenia gravis;
• violation of the function of the vestibular apparatus;
• azotemia;
• pretreatment with oto or nephrotoxic drugs.

Mode of application

Use amikacin intramuscularly or intravenously.

It is necessary to administer amikacin by intravenous infusion to adults and children using a volume of liquid sufficient for drip infusion within 60-90 minutes (at a rate of 50 drops in 1 min), and for newborns within 1-2 hours. The concentration of amikacin solution during administration should not exceed 5 mg / ml. Intravenous injection of amikacin must be carried out very slowly (within 2-7 minutes). A solution for parenteral administration should be prepared immediately before administration and used immediately after preparation.

The following solvents can be used for administration: 0.9% sodium chloride solution, 5% glucose solution, Ringers lactate solution for injection containing glucose (5%).

Application features

Pregnant women

The drug is contraindicated for use during pregnancy and lactation.

Children

The drug is recommended to be used with caution in premature and full-term infants, because due to the underdevelopment of the excretory system, the output of aminoglycosides can be lengthened, causing toxic effects.

Drivers

The likelihood of developing side effects from the central nervous system and sensory organs such as drowsiness, impaired neuromuscular transmission, discoordination of movements, and dizziness should be taken into account.

Overdose

It is possible that the drug and the nephrotoxic effect of the drug and signs of neuromuscular blockade appear, tinnitus, hearing loss, hearing disorders, skin rashes, headache, dizziness, chills, paresthesia, decreased renal function (before renal failure), respiratory depression or paralysis, toxic reactions (ataxia, urination disorders, thirst, loss of appetite, nausea, vomiting).

Treatment: to remove the blockade of neuromuscular transmission and its consequences - hemodialysis or peritoneal dialysis; anticholinesterase agents, calcium salts, mechanical ventilation, other symptomatic and supportive therapy. Amikacin should be reduced by continuous arteriovenous hemofiltration.

Side effects

Nausea, vomiting, diarrhea, impaired liver function (increased activity of hepatic transaminases, hyperbilirubinemia), anemia, leukopenia, granulocytopenia, thrombocytopenia, vasculitis, arterial hypotension, headache, drowsiness, neurotoxic effect (muscle twitching, numbness, tingling sensations, tingling, epilation) , violation of neuromuscular transmission (respiratory arrest).

Interaction

It is pharmaceutically incompatible with penicillins, heparin, cephalosporins, capreomycin, amphotericin B, hydrochlorothiazide, erythromycin, nitrofurantoin, vitamins B and C, and potassium chloride.

Storage conditions

Store in the original packaging at a temperature not exceeding 25 ° C. Do not freeze.

Keep out of the reach of children.

Shelf life is 2 years.