- Secure and encrypted payment processing
- We ship to over 40 countries including the USA, UK, Europe, Australia and Japan
- Guaranteed refund or reship if you haven't received your order
Aceclofenac is an NSAID that also has analgesic and antipyretic effects. in experimental models, it inhibits the development of edema and hyperemia, regardless of the nature of the inflammation. Studies of the mechanisms of action of this drug in both animals and humans have shown that aceclofenac most likely inhibits the secretion of prostaglandins and leukotrienes through reversible inhibition of cog. in a 4-day study of the skin tolerance (irritation) of an aertal cream, a comparative analysis with a placebo cream and twice distilled water revealed a less pronounced irritant effect of an aertal cream compared to other test substances.
In another study involving 12 volunteers, the size of the hyperemia site was evaluated under the influence of ultraviolet radiation before and after applying Aertal cream. It was found that after applying the cream, the size of the hyperemia site after 7 hours was less in the areas treated with aceclofenac compared with the areas treated with placebo and the control areas (untreated). Aertal cream has been proven to have anti-inflammatory and analgesic effects when applied topically to treat injuries of the musculoskeletal system. Comparative clinical studies have confirmed that the effectiveness of aceclofenac is at least comparable to the effectiveness of other topical preparations.
Clinical efficacy is combined with satisfactory local and systemic tolerance.
Therefore, Aertal cream is an effective drug for use in injuries or inflammatory diseases of the musculoskeletal system.
Pharmacokinetics Suction. Aertal cream is absorbed from the application area. It accumulates in the absorption zone, which contributes to an increase in anti-inflammatory activity, and gradually enters the systemic circulation in low concentrations, and therefore the risk of side effects, including from the gastrointestinal tract, is minimized.
Distribution. Aceclofenac is distributed throughout the body.
Aceclofenac is metabolized in the liver and excreted slowly, partially unchanged, with urine and feces.
Treatment of all types of local pain and inflammation due to any damage to the musculoskeletal system, including sports injuries.
Reducing the severity of inflammation of the tendons, ligaments, muscles and joints in cases of distension, overstrain or bruises, as well as in the complex therapy for the treatment of lumbago, torticollis and periarthrosis.
The product is intended for external use only and should not be applied under pressure dressings. Aertal should be applied 3 times a day with light massaging movements on the affected area. the dose used depends on the size of the affected area: 1.5–2 g aertal cream (approximately corresponds to a strip of cream 5–7 cm long).
There is no experience with Aertal cream in children, so Aertal cream is contraindicated in children.
Correction of the dosage regimen for the elderly is not required.
Hypersensitivity to aceclofenac or any of the excipients.
A history of hypersensitivity to other NSAIDs. Although a possible cross-hypersensitivity to diclofenac has not been confirmed, this drug is not recommended for patients with a history of hypersensitivity to diclofenac. Aceclofenac, by analogy with other NSAIDs, is contraindicated in patients in whom acetylsalicylic acid or NSAIDs cause asthma attacks, urticaria, or acute rhinitis.
Aertal cream has shown satisfactory local tolerance.
In some cases, mild or moderate local irritation is described, accompanied by flushing of the skin and itching, which disappear when treatment is discontinued.
In rare cases, Varicella Zoster virus in combination with NSAID treatment can cause serious complications in the form of infection of the skin and soft tissues.
In addition, there are separate reports of hypersensitivity reactions (from ≥1 / 1000 to 1/100) of the skin areas on which the cream was applied under the influence of intense sunlight without adequate protection from ultraviolet radiation.
Below is a table of adverse reactions, according to clinical studies and post-registration use of aceclofenac, filed in accordance with the classes of organ systems and frequency: very often (≥1 / 10); often (from ≥1 / 100 1/10); infrequently (from ≥1 / 1000 to 1/100); rarely (from ≥1 / 10,000 to 1/1000), very rarely (1/10 000).
|Class of systems
|Systemic disorders and complications at the injection site
|Bullous reactions (including Stevens-Johnson syndrome and toxic epidermal necrolysis)
In rare cases, serious skin problems have been reported.